The benches were warned after the incident, during which no punches were thrown and no ejections were issued.
With Donaldson and Grandal separated, the clubs clustered at home plate for several minutes, with White Sox manager Tony LaRussa and Yankees manager Aaron Boone both seeking clarification from home-plate umpire Nick Mahrley.
The Donaldson-Grandal dustup followed a similar jawing match between Donaldson and White Sox shortstop Tim Anderson after the third inning, which prompted the players to be separated as the Yankees left the playing field.
The third-inning Donaldson/Anderson fireworks were a callback to a May 13 game between the White Sox and Yankees at Guaranteed Rate Field. Both benches cleared following a first-inning play at third base that day, with Anderson having shoved Donaldson after being tagged.